Selected Publications



J.L. Nakamura. Considerations for carcinogenesis countermeasure development using mouse models. Life Sciences in Space Research 2022 Nov;35:158-162. PMID: 36336361

N.K. Bennett , H.J. Nakaoka, R. A. Okimoto, D. Laurent, Y. Sei, A.E. Horvai, T.G. Bivona, J. ten Hoeve, T. G. Graeber, K. Nakamura, J.L. Nakamura. Primary and metastatic tumors exhibit systems-level differences in dependence on mitochondrial respiratory function. PLoS Biol 2022 Sep 22;20(9) PMID: 36137002, PMCID: PMC9498964

D. Laurent, A.E. Smith, W.K. Bessler, M. Mendonca, H. Chin-Sinex, M. Descovich, A.E. Horvai, D.W. Clapp, J.L. Nakamura. Irradiation of Nf1 mutant mouse models of spinal plexiform neurofibromas drives pathologic disease progression and decreases survival. Neuro-Oncology Advances 2021 Apr 23;3(1). PMID: 34131650 PMCID: PMC8193912

D. Pucciarelli, S. Angus, C. Zhang, H. Nakaoka, G. Krishnamurthi, B. Huang, S. Bandyopadhyay, K. Shannon, G. Johnson, J.L. Nakamura. Inhibition of mTOR or MEK induces transcriptome and kinome re-modeling in Nf1 mutant tumors through reversible and irreversible mechanisms. Molecular Cancer Therapeutics. 2020 Aug 26 PMID: 32847978

N.K. Bennett, M. Darch, M.K. Nguyen, H. Nakaoka, D.Cousineau, M. Hirano, M. Schuelke, M. Emin, M. Kampmann, J.L. Nakamura, K. Nakamura. The ATPome Reveals Cross-Optimization of Metabolic Pathways and Therapeutic Strategies. Nature Communications. 2020 Aug 28;11 (1):4319. PMID: 32859923

V. Lavergne, A. Sabnis, A. Tulpule, P. Davidson, R. Goldsby, S. Braunstein, S. Fogh, P.K. Sneed, P. Menzel, K. Matthay, S. DuBois, A. Nakamura, D. Haas-Kogan, J.L. Nakamura. Germline MUTYH mutation in a pediatric cancer survivor developing a secondary malignancy. Journal of Pediatric Hematology/Oncology 2019 Dec 4. PMID: 31815884.

S. Bhatia, Y. Chen, F.L. Wong, L. Hageman, K. Smith, G. Friedman, J.P. Neglia, M. Arnold, L.M. Turcotte, P. de Blank, G.T. Armstrong, L.L. Robison, D.W. Clapp, K. Shannon, J.L. Nakamura, M.J. Fisher. Subsequent neoplasms after a primary tumor in patients with Neurofibromatosis type I. Journal of Clinical Oncology 2019 Sept 18 PMID: 31532722.

J. Ohja, A.J. deSmith, S. Gonseth, M. Zhou, H.M. Hansen, A. Sherborne, J. Nakamura, P.M. Bracci, K.M. Walsh, S.C. Finch, R.F. Reiss, M. Little, I. Dyagil, N. Gudzenko, D. Bazyka, J.L. Wiemels, L. Zablotska. Genetic characterization of somatic alterations in radiation-associated chronic lymphocytic leukemia. Environmental Health 2018 May 2;17(1):43. PMID: 29720177

B.A. Mendelsohn, M. Darch, N.K. Bennett, K. Yu, D. Pucciarelli, M. Horlbeck, L. Gilbert, W. Hyun, J.S. Weissman, M. Kampmann, J.L. Nakamura, K. Nakamura. Systematic Metabolic Reprogramming reveals mechanisms of energy failure and therapy. PLOS Biology 2018 Aug 27; 16(8). PMID: 30148842.

Davidson PR, Sherborne AL, Taylor B, Nakamura AO, Nakamura JL. A pooled mutational analysis identifies ionizing radiation-associated mutational signatures conserved between mouse and human malignancies. Sci Rep. 2017;7(1):7645. doi: 10.1038/s41598-017-07888-0. PubMed PMID: 28794481; PMCID: PMC5550450.

Sherborne AL, Lavergne V, Yu K, Lee L, Davidson PR, Mazor T, Smirnoff IV, Horvai AE, Loh M, DuBois SG, Goldsby RE, Neglia JP, Hammond S, Robison LL, Wustrack R, Costello JF, Nakamura AO, Shannon KM, Bhatia S, Nakamura JL. Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors. Clin Cancer Res. 2017;23(7):1852-61. doi: 10.1158/1078-0432.CCR-16-0610. PubMed PMID: 27683180

A.L. Sherborne, P.R. Davidson, K. Yu, A.O. Nakamura, M. Rashid, J.L. Nakamura. Mutational analysis of ionizing radiation-induced neoplasms. Cell Rep. 2015 Sep 22;12(11):1915-26. doi: 10.1016/ j.celrep.2015.08.015. Epub 2015 Sep 3. PMID: 26344771.


R. Mroue, B. Huang, S. Braunstein, A. Firestone, J.L. Nakamura. Loss of the imprinted gene Grb10 cooperates with Nf1 loss to promote tumorigenesis. PLOS Genetics. 2015 May 22;11(5). PMID: 26000738.


N. Li, D.J. Maly, Y.H. Chanthery, D. Sirkis, C.S. Hackett, J.L. Nakamura, M.S. Berger, C.D. James, K.M. Shokat, W.A. Weiss, A.I. Persson. A sequential regimen of radiotherapy followed by aurora kinase inhibition targets tumor-propogating cells in human glioblastoma.Molecular Cancer Therapeutics. 2015 Feb; 14(2); 419-28. PMID: 25522764.


S.D. Fouse, J.L. Nakamura, C.D. James, S. Chang, J.F. Costello.Sensitivity of primary glioblastoma cells to therapy is patient-specific and independent of the stem cell phenotype. Neuro-Oncology. 2014 Mar;16(3):361-71. PMID: 24311636.


S.E. Braunstein, J.L. Nakamura. Radiotherapy-induced malignancies: Review of epidemiology, pathobiology and evolving technical approaches for mitigating risk. Frontiers in Oncology. 2013;3:73. PMID: 23565507


M. Wahl, A. Hwang, J. Nakamura, I. Barani, S. Fogh, P. Sneed, M. McDermott, A. Sahgal, L. Ma. Individual Beam Sharpening Improves Composite Dose Fall-off Near a Target for Non-isocentric Cyberknife Radiosurgery. Technol Cancer Res Treat 2013 Aug;12(4):341-8. PMID: 23369157


Fogh S, Ma L, Gupta N, Sahgal A, Nakamura JL, Barani I, Sneed PK, McDermott M, Larson DA. High-precision volume-staged Gamma Knife surgery and equivalent hypofractionation dose schedules for treating large arteriovenous malformations. J Neurosurgery 2012 Dec; 117 Suppl: 115-9. PMID: 23205798


F L. Ma, S. Fogh, N. Gupta, A. Hwang, D. Pinnaduwage, J. Nakamura, I. Barani, M. McDermott, P. K. Sneed, D. Larson and A. Sahgal. A technique for achieving submillimeter accuracy of volume-staged stereotactic radiosurgery. Journal of Radiosurgery and SBRT. 2012; 2(1):11-17.


G. Choi, B. Huang, E. Pinarbasi, S.E. Braunstein, A.E. Horvai, S. Kogan, S. Bhatia, B. Faddegon, J.L. Nakamura. Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms. Cancer Res. 2012 Dec 15;72(24):6425-34.PMID: 23071067


Caballero JA, Sneed PK, Lamborn KR, Ma L, Denduluri S, Nakamura JL, Barani IJ, McDermott MW. Prognostic factors for survival in patients treated with stereotactic radiosurgery for recurrent brain metastases after prior whole brain radiotherapy. Int J Radiat Oncol Biol Phys. 2012 May 1;83(1):303-9.PMID: 22079723


Ma L, Lee L, Barani I, Hwang A, Fogh S, Nakamura J, McDermott M, Sneed P, Larson DA, Sahgal A. Shot sequencing based on biological equivalent dose considerations for multiple isocenter Gamma Knife radiosurgery. Phys Med Biol. 2011 Nov 21;56(22):7247-56.PMID: 22037677


Nakamura JL, Phong C, Pinarbasi E, Kogan SC, Vandenberg S, Horvai AE, Faddegon BA, Fiedler D, Shokat K, Houseman BT, Chao R, Pieper RO, Shannon K., Dose-dependent effects a focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice. Cancer Res. 2011 Jan 1;71(1):106-15.PMID: 21199799


Descovich M, Sneed PK, Barbaro NM, McDermott MW, Chuang CF, Barani IJ, Nakamura JL, Lijun M., A dosimetric comparison between Gamma Knife and CyberKnife treatment plans for trigeminal neuralgia. J Neurosurg. 2010 Dec;113 Suppl:199-206.PMID:21222296


L. Ma, A. Sahgal, C. Chuang, M. Descovich, P. Petti, V. Smith, L. Verhey, N. Barbaro, M. McDermott, K. Huang, J. Nakamura, P. Sneed, D. Larson. Functional Relationship between the volume of a near-target peripheral isodose line and its isodose value for Gamma Knife Radiosurgery. Radiosurgery 2010, Vol. 7, pp.75-83.DOI:10.1159/000288720


N. Kased, D.K. Binder, M.W. McDermott, J.L. Nakamura, K. Huang, M.S. Berger, W.M. Wara, P.K. Sneed. Gamma Knife Radiosurgery for Brain Metastases from Primary Breast Cancer. Int J Rad Oncol Biol Phys 2009 Nov 15;75(4):1132-40.Epub 2009 Apr 3. PMID:19345514


N. Kased, K. Huang, J.L. Nakamura, A. Sahgal, D.A. Larson, M.W. McDermott,P.K. Sneed. Gamma Knife Radiosurgery for brainstem metastases: the UCSF experience. J Neuro-Oncology 2008 Jan; 86(2): 195-205.


J.L. Nakamura, E. Garcia, R.O. Pieper. S6K1 plays a key role in glial transformation. Cancer Research, 2008 Aug 15;68(16):6516-23.


D.W. Golden, K.R. Lamborn, M.W. McDermott, S. Kunwar, W.M. Wara, J.L. Nakamura, P.K. Sneed. Prognostic Grading for Radiosurgical Treatment of Brain Metastases: Is One System Adequate? J Neurosurgery 2008 Dec (109): 77-86.


J.L. Nakamura, D.A. Haas-Kogan, R.O. Pieper. Glioma invasiveness responds variably to irradiation in a co-culture model. Int J Rad Oncol Biol Phys 2007; 69(3): 880-6.


J.L. Nakamura. The role of EGFR in the ppathogenesis of glioblastoma multiforme. Expert Opinion on Therapeutic Targets. 2007 Apr; 11(4) 463-72.


Nakamura JL, Haas-Kogan DA, Pieper RO., Glioma invasiveness responds variably to irradiation in a co-culture model. Int J Radiat Oncol Biol Phys. 2007 Nov 1;69(3):880-6.


Nakamura JL., The epidermal growth factor receptor in malignant gliomas: pathogenesis and therapeutic implications. Expert opinion on therapeutic targets. 2007 Apr;11(4):463-72. Review.