Research

About the Nakamura Lab

The Nakamura Lab integrates cancer biology, metabolism, and aging research to understand fundamental mechanisms of disease and to translate discoveries into clinical impact. Our multidisciplinary approach links cutting-edge experimental models with human studies, enabling a seamless pipeline from mechanistic insight to patient-focused applications.

Cancer Development & Aging

We investigate carcinogenesis—the biological processes that drive cancer formation—and how these processes overlap with mechanisms of aging.

Our lab has developed multiple mouse models of radiation-induced cancers and performed genomic analyses of both mouse and human tumors. These studies revealed strong parallels in their mutational landscapes, uncovering shared signatures of radiation exposure and aging.

Radiation-associated mutational signatures strikingly resemble those observed in aging tissues. This convergence raises new questions about how lifelong exposure and age-related mutational burden together shape cancer risk. Using epidemiologically informed models, we are now prospectively studying how cumulative radiation exposure influences mutational trajectories and cancer development across the lifespan.

Cancer Metabolism

We study the metabolic programs that enable tumors to grow, adapt, and spread in vivo. Using CRISPR-based genetic screens, we identify metabolic dependencies that distinguish primary tumors from metastatic disease. These studies reveal vulnerabilities that may be exploited for therapeutic development.

In parallel, we are advancing imaging technologies optimized for tracking tumor metabolism in living systems. Our goal is to define the metabolic networks that sustain tumor progression and translate these insights into targeted therapies that reshape cancer management.

Protecting Cognition in Aging

Cognitive decline is a major challenge for individuals undergoing cancer therapy, particularly older adults. We develop model systems to uncover how cancer- and treatment-related stressors affect the nervous system and contribute to neurological complications. 

Our translational research aims to identify biomarkers of cognitive resilience and susceptibility. By understanding who is most at risk—and why—we seek to inform personalized strategies that preserve cognitive health during and after cancer therapy. To this end, we are leading clinical research into both personalized and generalizable strategies to protect brain health.